Which of the following is NOT an indication for APAP?

APAP, or Auto-Adjusting Positive Airway Pressure, is a type of therapy used primarily for the treatment of obstructive sleep apnea (OSA). It automatically adjusts the pressure based on the user's breathing patterns throughout the night, which can enhance comfort and improve compliance.

The reason "severe hypoxia" is not an indication for APAP is that this condition typically reflects a critical status that requires immediate medical intervention beyond just adjusting airflow pressure. Severe hypoxia indicates that the patient is not receiving adequate oxygenation, which could stem from various issues that may not be directly resolved by pressure adjustments alone. In such cases, patients often require supplemental oxygen or other urgent treatments to stabilize their oxygen levels.

In contrast, conditions such as being non-compliant with CPAP, positional apneas, and REM-related apneas are situations where APAP can provide significant benefit. For patients who have difficulty adhering to continuous positive airway pressure therapy, APAP can be more comfortable and can help improve compliance with therapy. Positional apneas involve airway obstruction that occurs primarily in specific sleep positions, and APAP can adjust pressures as the patient changes positions during sleep. Similarly, REM-related apneas can also benefit from the pressure adjustments made by APAP, as these events often